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Memantine hydrochloride

Abstract

Memantine hydrochloride (Namenda; Forest/Merz), which acts to protect neurons against toxicity caused by overactivation of N-methyl-D-aspartate receptors, became the first drug to be approved by the US FDA for the treatment of moderate to severe Alzheimer's disease in October 2003, after its approval for the same indication in the European Union in 2002. What influence could this have on its market potential?

Memantine

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Figure 1: NMDA receptor antagonism.
Figure 2: Market for drugs to treat Alzheimer's disease.

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Correspondence to Andrea Witt.

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Witt, A., Macdonald, N. & Kirkpatrick, P. Memantine hydrochloride. Nat Rev Drug Discov 3, 109–110 (2004). https://doi.org/10.1038/nrd1311

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