Comment | Published:

Glimmers in illuminating the druggable genome

Nature Reviews Drug Discovery volume 17, pages 301302 (2018) | Download Citation

Much biomedical research continues to focus on a small proportion of the human genome that has already been studied intensively. The Illuminating the Druggable Genome programme, initiated as a pilot project by the US National Institutes of Health Common Fund in 2014, is now being implemented to accelerate the investigation of subsets of understudied proteins that have potential therapeutic relevance.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    et al. A comprehensive map of molecular drug targets. Nat. Rev. Drug Discov. 16, 19–34 (2017).

  2. 2.

    et al. Too many roads not taken. Nature 470, 163–165 (2011).

  3. 3.

    et al. Collating protein information to shed light on the druggable genome. Nucleic Acids Res. 45, D995–D1002 (2017).

  4. 4.

    et al. PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome. Nat. Struct. Mol. Biol. 22, 362–369 (2015).

  5. 5.

    et al. Zebrafish behavioral profiling identifies multi-target antipsychotic-like compounds. Nat. Chem. Biol. 12, 559–566 (2016).

Download references

Author information

Affiliations

  1. Office of the Director, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

    • Griffin Rodgers
  2. Office of the Director, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20817, USA.

    • Christopher Austin
    •  & Christine Colvis
  3. Division of Program Coordination, Planning, and Strategic Initiatives, National Institutes of Health, Bethesda, Maryland 20892, USA.

    • James Anderson
  4. Division of Diabetes, Endocrinology, and Metabolic Diseases. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

    • Aaron Pawlyk
    • , Ronald Margolis
    •  & Jenna Baker

Authors

  1. Search for Griffin Rodgers in:

  2. Search for Christopher Austin in:

  3. Search for James Anderson in:

  4. Search for Aaron Pawlyk in:

  5. Search for Christine Colvis in:

  6. Search for Ronald Margolis in:

  7. Search for Jenna Baker in:

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Aaron Pawlyk.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nrd.2017.252

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing