In 2015, academic-led trials provided evidence for safe de-escalation of adjuvant treatment in early stage breast cancer and answered important questions related to adjuvant regional irradiation and optimal first-line chemotherapy in advanced-stage disease. Furthermore, the development of novel therapies and potential tools for treatment tailoring will offer new hope to patients with breast cancer.
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References
Tolaney, S. M. et al. Adjuvant paclitaxel and trastuzumab for node-negative, HER2-positive breast cancer. N. Engl. J. Med. 372, 134–141 (2015).
Francis, P. A. et al. Adjuvant ovarian suppression in premenopausal breast cancer. N. Engl. J. Med. 372, 436–446 (2015).
Sparano, J. A. et al. Prospective validation of a 21-gene expression assay in breast cancer. N. Engl. J. Med. 373, 2005–2014 (2015).
Whelan, T. J. et al. Regional nodal irradiation in early-stage breast cancer. N. Engl. J. Med. 373, 307–316 (2015).
Poortmans, P. M. et al. Internal mammary and medial supraclavicular irradiation in breast cancer. N. Engl. J. Med. 373, 317–327 (2015).
Rugo, H. S. et al. Randomized phase III trial of paclitaxel once per week compared with nanoparticle albumin-bound nab-paclitaxel once per week or ixabepilone with bevacizumab as first-line chemotherapy for locally recurrent or metastatic breast cancer: CALGB 40502/NCCTG N063H (Alliance). J. Clin. Oncol. http://dx.doi.org/10.1200/jco.2014.59.5298 (2015).
Tutt, A. et al. Abstract S3-01: The TNT trial: a randomized phase III trial of carboplatin (C) compared with docetaxel (D) for patients with metastatic or recurrent locally advanced triple negative or BRCA1/2 breast cancer (CRUK/07/012). Cancer Res. 75, S3-01 (2015).
Finn, R. S. et al. The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study. Lancet Oncol. 16, 25–35 (2015).
Turner, N. C. et al. Palbociclib in hormone-receptor-positive advanced breast cancer. N. Engl. J. Med. 373, 209–219 (2015).
Emens, L. A. et al. Inhibition of PD-L1 by MPDL3280A leads to clinical activity in patients with metastatic triple-negative breast cancer. [abstract PD1-6], Presented at the San Antonio Breast Cancer Symposium (2014).
Nanda, R. et al. A phase Ib study of pembrolizumab (MK-3475) in patients with advanced triple-negative breast cancer. [abstract S1-09], Presented at the San Antonio Breast Cancer Symposium (2014).
Dirix, L. Y. et al. Avelumab (MSB0010718C), an anti-PD-L1 antibody, in patients with locally advanced or metastatic breast cancer: a phase Ib JAVELIN solid tumor trial. [abstract S1-04], Presented at the San Antonio Breast Cancer Symposium (2015).
Salgado, R. et al. Tumor-infiltrating lymphocytes and associations with pathological complete response and event-free survival in HER2-positive early-stage breast cancer treated with lapatinib and trastuzumab: a secondary analysis of the NeoALTTO trial. JAMA Oncol. 1, 448–454 (2015).
Gebhart, G. et al. Molecular imaging as a tool to investigate heterogeneity of advanced HER2-positive breast cancer and to predict patient outcome under trastuzumab emtansine (T-DM1): the ZEPHIR Trial. Ann. Oncol. http://dx.doi.org/10.1093/annonc/mdv577 (2015).
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M.J.P. declares she is a consultant for and receives honoraria from AstraZeneca, Invivis, MSD, Novartis, Pfizer, Radius, Roche-Genentech and Synthon. I.G. declares no competing interests.
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Piccart, M., Gingras, I. Academic research sheds light on issues that matter to patients. Nat Rev Clin Oncol 13, 67–68 (2016). https://doi.org/10.1038/nrclinonc.2015.236
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DOI: https://doi.org/10.1038/nrclinonc.2015.236