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Immunotherapy

Treatment of aggressive lymphomas with anti-CD19 CAR T cells

Adoptive immunotherapy using T cells genetically engineered to express a chimeric antigen receptor that targets CD19, a B-cell differentiation antigen, has demonstrated impressive efficacy in a range of B-lymphoid malignancies. The latest results demonstrate the potential of this approach in patients with chemotherapy-refractory diffuse large B-cell lymphoma.

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Figure 1: Treatment of patients with B-cell malignancies using anti-CD19 CAR T cells.

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Correspondence to Christopher A. Klebanoff.

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Klebanoff, C., Yamamoto, T. & Restifo, N. Treatment of aggressive lymphomas with anti-CD19 CAR T cells. Nat Rev Clin Oncol 11, 685–686 (2014). https://doi.org/10.1038/nrclinonc.2014.190

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