Two randomized controlled trials conducted within the SIGGAR study have reported efficacy results. In patients with symptoms of colorectal cancer, CT colonography should replace barium enema and is a good alternative to colonoscopy.
Key Points
CT colonography should replace barium enema as an imaging test in patients with symptoms of colorectal cancer and is a good alternative to colonoscopy.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Sosna, J. et al. Critical analysis of the performance of double-contrast barium enema for detecting colorectal polyps > or = 6 mm in the era of CT colonography. Am. J. Roentgenol. 190, 374–385 (2008).
Halligan, S. et al. Computed tomographic colonography versus barium enema for diagnosis of colorectal cancer or large polyps in symptomatic patients (SIGGAR): a multicentre randomised trial. Lancet http://dx.doi.org/10.1016/S0140–6736(12)62124–2.
Halligan, S. et al. Design of a multicentre randomized trial to evaluate CT colonography versus colonoscopy or barium enema for diagnosis of colonic cancer in older symptomatic patients: the SIGGAR study. Trials 8, 32 (2007).
von Wagner, C. et al. Patient acceptability of CT colonography compared with double contrast barium enema: results from a multicentre randomised controlled trial of symptomatic patients. Eur. Radiol. 21, 2046–2055 (2011).
Pickhardt, P. J., Hassan, C., Halligan, S. & Marmo, R. Colorectal cancer: CT colonography and colonoscopy for detection--systematic review and meta-analysis. Radiology 259, 393–405 (2011).
Atkin, W. et al. Computed tomographic colonography versus colonoscopy for investigation of patients with symptoms suggestive of colorectal cancer (SIGGAR): a multicentre randomised trial. Lancet http://dx.doi.org/10.1016/S0140–6736(12)62186–2.
von Wagner, C. et al. Patient acceptability and psychologic consequences of CT colonography compared with those of colonoscopy: results from a multicenter randomized controlled trial of symptomatic patients. Radiology 263, 723–731 (2012).
Mulhall, B. P., Veerappan, G. R. & Jackson, J. L. Meta-analysis: computed tomographic colonography. Ann. Intern. Med. 142, 635–650 (2005).
Lieberman, D., Moravec, M., Holub, J., Michaels, L. & Eisen, G. Polyp size and advanced histology in patients undergoing colonoscopy screening: implications for CT colonography. Gastroenterology 135, 1100–1105 (2008).
Rex, D. K. et al. Serrated lesions of the colorectum: review and recommendations from an expert panel. Am. J. Gastroenterol. 107, 1315–1329 (2012).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The author performs educational activities and/or collaborative research with SIGGAR researchers.
Rights and permissions
About this article
Cite this article
Stoker, J. CT colonography has finally arrived. Nat Rev Clin Oncol 10, 254–255 (2013). https://doi.org/10.1038/nrclinonc.2013.54
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrclinonc.2013.54