Researchers at the University Hospital of Cologne, Germany, have conducted a head-to-head comparison of rituximab and obinutuzumab (GA101). The study assigned 781 patients with chronic lymphocytic leukaemia (average age 73 years) to three treatment arms: in the first arm patients received GA101 in combination with the standard chemotherapy chlorambucil (Clb; GClb, n = 333), in the second arm patients received rituximab and Clb (RClb, n = 330), and Clb alone in the third group (n = 118). Patients in the GClb group experienced prolonged median progression-free survival (26.7 months) compared with the RClb arm (15.2 months) and higher overall response rate (78% versus 65%) with acceptable toxicity.
References
Goede, V. et al. Head-to-head comparison of obinutuzumab (GA101) plus chlorambucil (Clb) versus rituximab plus Clb in patients with chronic lymphocytic leukemia (CLL) and co-existing medical conditions (comorbidities): final stage II results of the CLL11 trial [abstract]. Blood 122, a6 (2013)
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More-effective treatment for patients with comorbidities. Nat Rev Clin Oncol 11, 67 (2014). https://doi.org/10.1038/nrclinonc.2013.239
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DOI: https://doi.org/10.1038/nrclinonc.2013.239