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Haematological cancer

Richter's transformation in CLL—a distinct lymphoma

Nature Reviews Clinical Oncology volume 11, pages 6–8 (2014)Cite this article

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A landmark study has delineated and identified the genetic pathways that drive the natural course of chronic lymphocytic leukaemia (CLL) B cells into Richter's transformation. CLL-related Richter's transformation is a distinct lymphoma, and poses various questions about B-cell ontogeny and relevance of B cell receptor signalling inhibitors.

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Acknowledgements

K. H. Young is supported by Institutional Research Grant Award, an MD Anderson Lymphoma Specialized Programs of Research Excellence (SPORE), Research Development Program Award, and an MD Anderson Myeloma SPORE Research Development Program Award. The lymphoma and myeloma research programs are kindly supported by National Cancer Institute and National Institutes of Health grants.

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Authors and Affiliations

  1. Department of Leukemia, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, 77030-4009, TX, USA

    Preetesh Jain

  2. Department of Haematopathology, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, 77030-4009, TX, USA

    Ken H. Young

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  1. Preetesh Jain
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Correspondence to Ken H. Young.

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The authors declare no competing financial interests.

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Jain, P., Young, K. Richter's transformation in CLL—a distinct lymphoma. Nat Rev Clin Oncol 11, 6–8 (2014). https://doi.org/10.1038/nrclinonc.2013.229

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