Although signalling through the Wnt/β-catenin pathway is associated with pancreatic ductal adenocarcinoma, only now has this pathway been shown to be critical for tumorigenesis. This was shown through experiments on β-catenin-null acinar cells, which could not undergo metaplastic transformation to ductal cells—a process central to the development of premalignant lesions. Furthermore, targeting the Wnt pathway with a specific antibody (OMP-18R5) in a transgenic mouse model of pancreatic cancer revealed normal acinar structures and fewer lesions than untreated mice.
ORIGINAL RESEARCH PAPER
Zhang, Y. et al. Canonical Wnt signaling is required for pancreatic carcinogenesis. Cancer Res. doi:10.1158/0008-5472.CAN-12-4384
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Wnt signalling required for pancreatic carcinogenesis. Nat Rev Clin Oncol 10, 428 (2013). https://doi.org/10.1038/nrclinonc.2013.116
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DOI: https://doi.org/10.1038/nrclinonc.2013.116