Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Urological cancer

Aspirin and the risk of prostate cancer mortality

The observational registry CaPSURE study reported that men with prostate cancer who were taking aspirin were less likely to die of prostate cancer than nonusers. This favourable effect seems to be stronger than that observed in a pooled analysis of randomized clinical trials of aspirin, and in other observational studies.

Key Points

  • In a follow-up study of patients with prostate cancer, aspirin was related to an appreciable decrease in prostate cancer mortality

  • This decrease has been related to a favourable action of aspirin on thrombosis

  • Observational studies suggest a modest decrease in prostate cancer risk among aspirin users

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Choe, K. S. et al. Aspirin use and the risk of prostate cancer mortality in men treated with prostatectomy or radiotherapy. J. Clin. Oncol. 30, 3540–3544 (2012).

    Article  CAS  Google Scholar 

  2. Bambace, N. M. & Holmes, C. E. The platelet contribution to cancer progression. J. Thromb. Haemost. 9, 237–249 (2011).

    Article  CAS  Google Scholar 

  3. Gay, L. J. & Felding-Habermann, B. Contribution of platelets to tumour metastasis. Nat. Rev. Cancer 11, 123–134 (2011).

    Article  CAS  Google Scholar 

  4. Camerer, E. et al. Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis. Blood 104, 397–401 (2004).

    Article  CAS  Google Scholar 

  5. Cuzick, J. et al. Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement. Lancet Oncol. 10, 501–507 (2009).

    Article  CAS  Google Scholar 

  6. Rothwell, P. M. et al. Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials. Lancet 379, 1591–1601 (2012).

    Article  CAS  Google Scholar 

  7. Thun, M. J., Henley, S. J. & Patrono, C. Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues. J. Natl Cancer Inst. 94, 252–266 (2002).

    Article  CAS  Google Scholar 

  8. Brown, J. R. & DuBois, R. N. COX-2: a molecular target for colorectal cancer prevention. J. Clin. Oncol. 23, 2840–2255 (2005).

    Article  CAS  Google Scholar 

  9. Bosetti, C., Rosato, V., Gallus, S. & La Vecchia, C. Aspirin and urologic cancer risk: an update. Nat. Rev. Urol. 9, 102–110 (2012).

    Article  CAS  Google Scholar 

  10. Bosetti, C., Rosato, V., Gallus, S., Cuzick, J. & La Vecchia, C. Aspirin and cancer risk: a quantitative review to 2011. Ann. Oncol. 23, 1403–1415 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Carlo La Vecchia.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

La Vecchia, C., Bosetti, C. Aspirin and the risk of prostate cancer mortality. Nat Rev Clin Oncol 9, 616–617 (2012). https://doi.org/10.1038/nrclinonc.2012.182

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrclinonc.2012.182

This article is cited by

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer