In patients with acute myeloid leukaemia (AML) in first complete remission, reduced-intensity conditioning (RIC) regimens have been developed to minimize toxicity after allogeneic stem cell transplantation. Now, a randomized phase III trial that compared standard conditioning with RIC, showed that nonrelapse mortality, disease-free survival and overall survival were comparable, but grade 3 or 4 oral mucositis was lower with the RIC regimen, indicating that this is the preferred option.
ORIGINAL RESEARCH PAPER
Bornhäuser, M. et al. Reduced-intensity conditioning versus standard conditioning before allogeneic haemopoietic cell transplantation in patients with acute myeloid leukaemia in first complete remission: a prospective, open-label randomised phase 3 trial. Lancet Oncol. doi:10.1016/S1470-2045(12)70349-2
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Reduced-intensity conditioning preferred for AML. Nat Rev Clin Oncol 9, 611 (2012). https://doi.org/10.1038/nrclinonc.2012.176
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DOI: https://doi.org/10.1038/nrclinonc.2012.176