The eradication of solid tumours using radiotherapy has long been one of the most powerful weapons in our treatment arsenal. Now, researchers investigating ultrasound-mediated microbubble vascular disruption have shown that this technique can enhance tumour response to radiation. The work was carried out in a human prostate cancer xenograft mouse model and showed that the combination of the microbubbles with the radiotherapy was 10-fold more effective at killing cancer cells than radiotherapy alone. This finding indicates that the two therapies work synergistically to eliminate cancer cells. Furthermore, the mechanism of action seems to be via the induction of ceramide-related endothelial cell apoptosis, leading to vascular disruption. The results of this study indicate that this dual technique might be a method to enhance tumour response using a low radiation dose, but a lot of work remains to be done.