Despite the improved progression-free survival and overall survival demonstrated by cisplatin–gemcitabine chemoradiation in a phase III randomized trial in patients with stage IIB to IVA cervical cancer, the acute and chronic toxic effects urge caution before embracing this as a new treatment paradigm.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Dueñas-González, A. et al. A phase III, open-label, randomized study comparing concurrent gemcitabine plus cisplatin and radiation followed by adjuvant gemcitabine and cisplatin versus concurrent cisplatin and radiation in patients with stage IIB to IVA carcinoma of the cervix. J. Clin. Oncol. 29, 1678–1685 (2011).
Pattaranutaporn, P. et al. Phase II study of concurent gemcitabine and radiotherapy in locally advanced stage IIIB cervical carcinoma. Gynecol. Oncol. 81, 404–407 (2001).
Zarbá, J. J. et al. A phase I-II study of weekly cisplatin and gemcitabine with concurrent radiotherapy in locally advanced cervical cancer. Ann. Oncol. 14, 1285–1290 (2003).
Umanzor, J. et al. Concurrent cisplatin/gemcitabine along with radiotherapy in locally advanced cervical carcinoma: a phase II trial. Gynecol. Oncol. 100, 70–75 (2006).
Dueñas-Gonzáles, A. et al. Pathologic response and toxicity assessment of chemoradiotherapy with cisplatin versus cisplatin plus gemcitabine in cervical cancer: a randomized phase II study. Int. J. Radiat. Oncol. Biol. Phys. 61, 817–823 (2005).
Eifel, P. J., Levenback, C., Wharton, J. T. & Oswald, M. J. Time course and incidence of late complications in patients treated with radiation therapy for FIGO stage IB carcinoma of the uterine cervix. Int. J. Radiat. Oncol. Biol. Phys. 32, 1289–1300 (1995).
Rose, P. G., Degeest, K., McMeekin, S. & Fusco, N. A phase I study of gemcitabine followed by cisplatin concurrent with whole pelvic radiation therapy in locally advanced cervical cancer: a Gynecologic Oncology Group study. Gynecol. Oncol. 107, 274–279 (2007).
Swisher, E. M. et al. Weekly gemcitabine and cisplatin in combination with pelvic radiation in the primary therapy of cervical cancer: a phase I trial of the Puget Sound Oncology Consortium. Gynecol. Oncol. 101, 429–435 (2006).
Lorvidhaya, V. et al. Concurrent mitomycin C, 5-flourouracil, and radiotherapy in the treatment of locally advanced carcinoma of the cervix: a randomized trial. Int. J. Radiat. Oncol. Biol. Phys. 55, 1226–1232 (2003).
Monk, B. J. et al. Phase III trial of four cisplatin-containing doublet combinations in stage IVB, recurrent, or persistent cervical carcinoma: a Gynecologic Oncology Group study. J. Clin. Oncol. 27, 4649–4655 (2009).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Rose, P. New treatment paradigm for locally advanced cervical cancer?. Nat Rev Clin Oncol 8, 388–390 (2011). https://doi.org/10.1038/nrclinonc.2011.85
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrclinonc.2011.85