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Hypoxia modification with radiotherapy for bladder cancer

The outcomes in bladder cancer treated with radiotherapy are suboptimal. Recently, Hoskin et al. reported improved survival in patients with bladder cancer treated with radiation therapy with concurrent hypoxia-modification therapy. These results are promising but must be viewed in the context of previous studies and alternative treatment approaches.

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References

  1. Ott, O. J. et al. Radiochemotherapy for bladder cancer. Clin. Oncol. (R. Coll. Radiol.) 21, 557–565 (2009).

    Article  CAS  Google Scholar 

  2. Kaanders, J. H., J. Bussink, J. & van der Kogel, A. J. Clinical studies of hypoxia modification in radiotherapy. Semin. Radiat. Oncol. 14, 233–240 (2004).

    Article  PubMed  Google Scholar 

  3. Sealy, R., Cridland, S., Barry, L. & Norris, R. Irradiation with misonidazole and hyperbaric oxygen: final report on a randomized trial in advanced head and neck cancer. Int. J. Radiat. Oncol. Biol. Phys. 12, 1343–1346 (1986).

    Article  CAS  PubMed  Google Scholar 

  4. Hoskin, P. J., Rojas, A. M., Bentzen, S. M. & Saunders, M. I. Radiotherapy with concurrent carbogen and nicotinamide in bladder carcinoma. J. Clin. Oncol. 28, 4912–4918 (2010).

    Article  PubMed  Google Scholar 

  5. Milosevic, M. et al. Radiotherapy for bladder cancer. Urology 69 (1 Suppl.), 80–92 (2007).

    Article  PubMed  Google Scholar 

  6. Pos, F. & Remeijer, P. Adaptive management of bladder cancer radiotherapy. Semin. Radiat. Oncol. 20, 116–120 (2010).

    Article  PubMed  Google Scholar 

  7. Chai, X. et al. Behavior of lipiodol markers during image guided radiotherapy of bladder cancer. Int. J. Radiat. Oncol. Biol. Phys. 77, 309–314 (2010).

    Article  CAS  PubMed  Google Scholar 

  8. Pos, F. et al. Lipiodol injection for target volume delineation and image guidance during radiotherapy for bladder cancer. Radiother. Oncol. 93, 364–367 (2009).

    Article  CAS  PubMed  Google Scholar 

  9. Rödel, C. & Sauer, R. What is the role of radiotherapy in bladder-preserving cancer therapy? Nat. Clin. Pract. Oncol. 2, 4–5 (2005).

    Article  PubMed  Google Scholar 

  10. Coppin, C. M. et al. Improved local control of invasive bladder cancer by concurrent cisplatin and preoperative or definitive radiation. The National Cancer Institute of Canada Clinical Trials Group. J. Clin. Oncol. 14, 2901–2907 (1996).

    Article  CAS  PubMed  Google Scholar 

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Gospodarowicz, M. Hypoxia modification with radiotherapy for bladder cancer. Nat Rev Clin Oncol 8, 129–130 (2011). https://doi.org/10.1038/nrclinonc.2011.5

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