The outcomes in bladder cancer treated with radiotherapy are suboptimal. Recently, Hoskin et al. reported improved survival in patients with bladder cancer treated with radiation therapy with concurrent hypoxia-modification therapy. These results are promising but must be viewed in the context of previous studies and alternative treatment approaches.
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References
Ott, O. J. et al. Radiochemotherapy for bladder cancer. Clin. Oncol. (R. Coll. Radiol.) 21, 557–565 (2009).
Kaanders, J. H., J. Bussink, J. & van der Kogel, A. J. Clinical studies of hypoxia modification in radiotherapy. Semin. Radiat. Oncol. 14, 233–240 (2004).
Sealy, R., Cridland, S., Barry, L. & Norris, R. Irradiation with misonidazole and hyperbaric oxygen: final report on a randomized trial in advanced head and neck cancer. Int. J. Radiat. Oncol. Biol. Phys. 12, 1343–1346 (1986).
Hoskin, P. J., Rojas, A. M., Bentzen, S. M. & Saunders, M. I. Radiotherapy with concurrent carbogen and nicotinamide in bladder carcinoma. J. Clin. Oncol. 28, 4912–4918 (2010).
Milosevic, M. et al. Radiotherapy for bladder cancer. Urology 69 (1 Suppl.), 80–92 (2007).
Pos, F. & Remeijer, P. Adaptive management of bladder cancer radiotherapy. Semin. Radiat. Oncol. 20, 116–120 (2010).
Chai, X. et al. Behavior of lipiodol markers during image guided radiotherapy of bladder cancer. Int. J. Radiat. Oncol. Biol. Phys. 77, 309–314 (2010).
Pos, F. et al. Lipiodol injection for target volume delineation and image guidance during radiotherapy for bladder cancer. Radiother. Oncol. 93, 364–367 (2009).
Rödel, C. & Sauer, R. What is the role of radiotherapy in bladder-preserving cancer therapy? Nat. Clin. Pract. Oncol. 2, 4–5 (2005).
Coppin, C. M. et al. Improved local control of invasive bladder cancer by concurrent cisplatin and preoperative or definitive radiation. The National Cancer Institute of Canada Clinical Trials Group. J. Clin. Oncol. 14, 2901–2907 (1996).
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Gospodarowicz, M. Hypoxia modification with radiotherapy for bladder cancer. Nat Rev Clin Oncol 8, 129–130 (2011). https://doi.org/10.1038/nrclinonc.2011.5
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DOI: https://doi.org/10.1038/nrclinonc.2011.5