Scientists have developed a 38-gene classifier that can accurately predict patients who are at risk of developing leukemia. Gene expression was assessed in CD34+ cells from patients who developed therapy-related myelodysplasia or acute myeloid leukemia (t-MDS/AML) after transplantation and compared the results with control patients who did not develop t-MDS/AML. In an independent cohort, this classifier accurately distinguished patients who developed t-MDS/AML from those who did not, indicating the use of this classifier for determining those at risk for this complication.
ORIGINAL RESEARCH PAPER
Li, L. et al. Altered hematopoietic cell gene expression precedes development of therapy-related myelodysplasia/acute myeloid leukemia and identifies patients at risk. Cancer Cell 20, 591–605 (2011)
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Gene classifier helps identify therapy for leukemia. Nat Rev Clin Oncol 9, 4 (2012). https://doi.org/10.1038/nrclinonc.2011.185
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DOI: https://doi.org/10.1038/nrclinonc.2011.185
