Pelvic lymphadenectomy offers no therapeutic benefit to women diagnosed with early-stage endometrial cancer according to a new study. Lymphadenectomy can only be recommended as part of a clinical trial in this disease setting; however, it can offer valuable staging information in those with advanced disease.
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References
Creutzberg, C. L. et al. Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomized trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma. Lancet 355, 1404–1411 (2000).
Keys, H. M. et al. A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group Study. Gynecol. Oncol. 92, 744–751 (2004).
Kilgore, L. C. et al. Adenocarcinoma of the endometrium: survival comparisons of patients with and without pelvic node sampling. Gynecol. Oncol. 56, 29–33 (1995).
Chan, J. K. et al. Therapeutic role of lymph node resection in endometrioid corpus cancer: a study of 12,333 patients. Cancer 107, 1823–1830 (2006).
ASTEC study group et al. Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomised study. Lancet 373, 125–136 (2009).
Benedetti Panici, P. et al. Systematic pelvic lymphadenectomy vs no lymphadenectomy in early-stage endometrial carcinoma: randomized clinical trial. J. Natl. Cancer Inst. 100, 1707–1716 (2008).
Chan, J. K. et al. Lymphadenectomy in endometrioid uterine cancer staging: how many lymph nodes are enough? A study of 11,443 patients. Cancer 109, 2454–2460 (2007).
Cragun, J. M. et al. Retrospective analysis of selective lymphadenectomy in apparent early-stage endometrial cancer. J. Clin. Oncol. 23, 3668–3675 (2005).
Mariani, A. et al. Prospective assessment of lymphatic dissemination in endometrial cancer: a paradigm shift in surgical staging. Gynecol. Oncol. 109, 11–18 (2008).
Creasman, W. T. et al. Surgical pathologic spread patterns of endometrial cancer. A Gynecologic Oncology Group Study. Cancer 60 (8 Suppl.), 2035–2041 (1987).
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Resnick, K., Cohn, D. & Fowler, J. Role of lymphadenectomy in the staging of endometrial cancer. Nat Rev Clin Oncol 6, 382–384 (2009). https://doi.org/10.1038/nrclinonc.2009.88
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DOI: https://doi.org/10.1038/nrclinonc.2009.88