The EICESS-92 trial compared the efficacy of cyclophosphamide and ifosfamide in patients with Ewing sarcoma. Subgroup analysis suggested that patients with large, localized tumors benefited from the addition of etoposide, whereas patients with metastases did not.
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DuBois, S., Grier, H. The role of ifosfamide and etoposide in Ewing sarcoma. Nat Rev Clin Oncol 6, 251–253 (2009). https://doi.org/10.1038/nrclinonc.2009.25
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DOI: https://doi.org/10.1038/nrclinonc.2009.25
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