Cardiac regeneration in 2017

Novel paradigms in the fight against heart failure

Important milestones in cardiac regenerative medicine that will define future research were reached in 2017: demonstration of adult cardiomyocyte renewal capacity, recognition of the importance of the extracellular matrix and the higher regenerative efficacy of repetitive dose protocols, and the publication of human data supporting paracrine effects of stem cell therapies and guidelines from TACTICS, the first international alliance on cardiac regenerative medicine.

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Figure 1: 2017 insights for the evolution of cardiac regenerative medicine.

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Acknowledgements

The author thanks Andreu Climent, Ricardo Sanz-Ruiz, and Ana Fernández-Baza for their outstanding contribution to this work. F.F.-A. is supported by grants from the Spanish Ministry of Science and Innovation (RTC-2015–4398, RTC- 2016–4911), Instituto de Salud Carlos III (PI13- 01882 and PI16-01123), Red de Investigación Cardiovascular (RIC. RD12.0042.0001), Red de Terapia Celular (TERCEL. RD12.0019.0021), and CIBERCV (CB16-11-00292), and is co-financed with FEDER funds.

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Correspondence to Francisco Fernández-Avilés.

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Fernández-Avilés, F. Novel paradigms in the fight against heart failure. Nat Rev Cardiol 15, 73–74 (2018). https://doi.org/10.1038/nrcardio.2017.218

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