Cardiac regeneration in 2017

Novel paradigms in the fight against heart failure

Important milestones in cardiac regenerative medicine that will define future research were reached in 2017: demonstration of adult cardiomyocyte renewal capacity, recognition of the importance of the extracellular matrix and the higher regenerative efficacy of repetitive dose protocols, and the publication of human data supporting paracrine effects of stem cell therapies and guidelines from TACTICS, the first international alliance on cardiac regenerative medicine.

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Figure 1: 2017 insights for the evolution of cardiac regenerative medicine.


  1. 1

    Lázár, E., Sadek, H. A. & Bergmann, O. Cardiomyocyte renewal in the human heart: insights from the fall-out. Eur. Heart J. 38, 2333–2342 (2017).

    Article  Google Scholar 

  2. 2

    Wang, W. E. et al. Dedifferentiation, proliferation, and redifferentiation of adult mammalian cardiomyocytes after ischemic injury. Circulation 136, 834–848 (2017).

    Article  Google Scholar 

  3. 3

    Bassat, E. et al. The extracellular matrix protein agrin promotes heart regeneration in mice. Nature 547, 179–184 (2017).

    CAS  Article  Google Scholar 

  4. 4

    Guo, Y. et al. Repeated doses of cardiac mesenchymal cells are therapeutically superior to a single dose in mice with old myocardial infarction. Basic Res. Cardiol. 112, 18 (2017).

    Article  Google Scholar 

  5. 5

    Wollert, K. C. et al. Intracoronary autologous bone marrow cell transfer after myocardial infarction: the BOOST-2 randomised placebo-controlled clinical trial. Eur. Heart J. 38, 2936–2943 (2017).

    CAS  Article  Google Scholar 

  6. 6

    Fernández-Avilés, F. et al. Global position paper on cardiovascular regenerative medicine. Eur. Heart J. 38, 2532–2546 (2017).

    Article  Google Scholar 

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The author thanks Andreu Climent, Ricardo Sanz-Ruiz, and Ana Fernández-Baza for their outstanding contribution to this work. F.F.-A. is supported by grants from the Spanish Ministry of Science and Innovation (RTC-2015–4398, RTC- 2016–4911), Instituto de Salud Carlos III (PI13- 01882 and PI16-01123), Red de Investigación Cardiovascular (RIC. RD12.0042.0001), Red de Terapia Celular (TERCEL. RD12.0019.0021), and CIBERCV (CB16-11-00292), and is co-financed with FEDER funds.

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Correspondence to Francisco Fernández-Avilés.

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Fernández-Avilés, F. Novel paradigms in the fight against heart failure. Nat Rev Cardiol 15, 73–74 (2018).

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