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Lipids

A hole in the diet–heart hypothesis?

Newly published data recovered from a large, randomized, controlled trial conducted >4 decades ago show no difference in mortality between individuals with a diet rich in saturated fat and those with a diet rich in linoleic acid, despite the cholesterol-lowering effect of the latter. These findings challenge the widely accepted diet–heart hypothesis.

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Correspondence to Philip C. Calder.

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Calder, P. A hole in the diet–heart hypothesis?. Nat Rev Cardiol 13, 385–386 (2016). https://doi.org/10.1038/nrcardio.2016.78

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