Ischaemic cardiomyopathy leads to destruction of cardiomyocytes beyond the regenerative potential of the adult human heart. The murine heart can regenerate in utero and shortly after birth, but oxidative stress eventually arrests cardiomyocyte division. Chronic hypoxia in mice has now been shown to induce the cell cycle in cardiomyocytes, resulting in cardiac regeneration.
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This work is supported by NIH grants NIH HL119230 and HL117986.
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Natarajan, N., Lee, R. Suffocating the heart to stimulate regeneration. Nat Rev Cardiol 14, 7–8 (2017). https://doi.org/10.1038/nrcardio.2016.197
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DOI: https://doi.org/10.1038/nrcardio.2016.197