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Heart failure

CA125-guided therapy reduces AHF rehospitalizations

Nature Reviews Cardiology volume 13, pages 634–635 (2016)Cite this article

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Carbohydrate antigen 125 (CA125)-guided treatment of acute heart failure (AHF) reduces the rate of rehospitalizations compared with standard of care (SOC). This finding was reported by the CHANCE-HF investigators and published in JACC: Heart Failure.

In total, 380 patients discharged for AHF were enrolled into the trial; 187 were assigned to receive CA125-guided therapy, and 193 were assigned to SOC. The CA125 strategy involved a prespecified algorithm designed to maintain the levels of CA125 at 35 U/ml or less by increasing the number of monitoring visits, enforcing statin use, and by diuretic dose optimization. The primary outcome end point was 1-year composite of death or AHF readmission.

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References

  1. Núñez, J. et al. Carbohydrate antigen 125–guided therapy in acute heart failure: CHANCE-HF: a randomized study. JACC Heart Fail. http://dx.doi.org/10.1016/j.jchf.2016.06.007 (2016)

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Authors
  1. Karina Huynh
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ter Maaten J. M. et al. Diuretic response in acute heart failure — pathophysiology, evaluation, and therapy. Nat. Rev. Cardiol. 12, 184–192 (2015)

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Huynh, K. CA125-guided therapy reduces AHF rehospitalizations. Nat Rev Cardiol 13, 634–635 (2016). https://doi.org/10.1038/nrcardio.2016.142

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  • DOI: https://doi.org/10.1038/nrcardio.2016.142

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