The MATRIX Investigators have published the findings of their randomized, superiority trial comparing radial and femoral access for coronary angiography and percutaneous coronary intervention in 8,404 patients with an acute coronary syndrome (ACS). At 30 days, net adverse clinical events had occurred in fewer of the patients in the radial access group (9.8% vs 11.7% with femoral access; RR 0.83, 95% CI 0.73–0.96; P = 0.0092), mainly owing to fewer instances of major BARC 3 or 5 bleeding (1.6% vs 2.3%; RR 0.67, 95% CI 0.49–0.92; P = 0.0128) and all-cause death (1.6% vs 2.2%; RR 0.72, 95% CI 0.53–0.99; P = 0.045). The investigators conclude that “altogether, the results ... suggest that radial access should become the default approach in patients with an ACS undergoing invasive management.”