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Biomarkers

Novel troponin immunoassay for early ACS rule-out

Nature Reviews Cardiology volume 13, pages 9–10 (2016)Cite this article

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The introduction of a new high-sensitivity troponin immunoassay might revolutionize the way acute coronary syndrome is diagnosed. The high analytical sensitivity of the assay enables earlier and more accurate identification of myocardial injury than with currently used methods, and also allows for the safe discharge of patients without myocardial ischaemia.

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Figure 1: The evolution of cardiac biomarkers for the diagnosis of acute coronary syndrome.

References

  1. Makam, A. N. & Nguyen, O. K. Use of cardiac biomarker testing in the emergency department. JAMA Intern. Med. 175, 67–75 (2015).

    Article  Google Scholar 

  2. Cervellin, G. & Lippi, G. Of MIs and men — a historical perspective on the diagnostics of acute myocardial infarction. Semin. Thromb. Hemost. 40, 535–543 (2014).

    Article  CAS  Google Scholar 

  3. Thygesen, K. et al. Third universal definition of myocardial infarction. Circulation 126, 2020–2035 (2012).

    Article  Google Scholar 

  4. Lippi, G. & Cervellin, G. Do we really need high-sensitivity troponin immunoassays in the emergency department? Maybe not. Clin. Chem. Lab. Med. 52, 205–212 (2014).

    CAS  Google Scholar 

  5. Shah, A. S. et al. High-sensitivity cardiac troponin I at presentation in patients with suspected acute coronary syndrome: a cohort study. Lancet http://dx.doi.org/10.1016/S0140-6736(15)00391-8.

  6. Reichlin, T. et al. One-hour rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T. Arch. Intern. Med. 172, 1211–1218 (2012).

    Article  Google Scholar 

  7. Druey, S. et al. Early rule-out and rule-in of myocardial infarction using sensitive cardiac troponin I. Int. J. Cardiol. 195, 163–170 (2015).

    Article  Google Scholar 

  8. Lippi, G. & Cervellin, G. High-sensitivity troponin T is more susceptible than high-sensitivity troponin I to impaired renal function. Am. J. Cardiol. 112, 1985 (2013).

    Article  CAS  Google Scholar 

  9. Carro, A. & Kaski, J. C. Myocardial infarction in the elderly. Aging Dis. 2, 116–137 (2011).

    Google Scholar 

Download references

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  1. Section of Clinical Biochemistry, University of Verona, P.le Ludovico Scuro 10, Verona, 37134, Italy

    Giuseppe Lippi

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  1. Giuseppe Lippi
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Correspondence to Giuseppe Lippi.

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The author declares no competing financial interests.

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Lippi, G. Novel troponin immunoassay for early ACS rule-out. Nat Rev Cardiol 13, 9–10 (2016). https://doi.org/10.1038/nrcardio.2015.174

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