Over the past decade, we have witnessed the unparalleled success of statins to treat dyslipidaemia. Target identification by Mendelian randomization, human monoclonal antibodies, gene therapy, RNA-based targets, and atherogenic lipoproteins other than LDL cholesterol have fuelled intense development efforts that might bear fruit in the very near future.
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J.J.P.K. declares that he has acted as a consultant and received honouraria from the following companies: Aegerion, Amgen, AstraZeneca, Atheronova, Boehringer Ingelheim, Catabasis, Cerenis, CSL Behring, Dezima Pharmaceuticals, Eli Lilly, Esperion, Genzyme, Isis, Merck, Novartis, Omthera, Pronova, Regeneron, Sanofi, The Medicines Company, UniQure, and Vascular Biogenics.
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Kastelein, J. Resurgence of targets and compounds to treat dyslipidaemia. Nat Rev Cardiol 11, 629–631 (2014). https://doi.org/10.1038/nrcardio.2014.132
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DOI: https://doi.org/10.1038/nrcardio.2014.132
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