In the POST trial, mechanical ischaemic postconditioning did not have a significant cardioprotective effect in patients with ST-segment elevation myocardial infarction. However, the sample size, the principal end point (ST-segment regression), and the postconditioning protocol used are important limitations in this trial. Whether mechanical postconditioning has cardioprotective clinical benefits remains unanswered.
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Ovize, M., Mewton, N. Ischaemic POSTconditioning—a long harvest for a little corn. Nat Rev Cardiol 11, 8–10 (2014). https://doi.org/10.1038/nrcardio.2013.173
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DOI: https://doi.org/10.1038/nrcardio.2013.173