In the Diuretic Optimization Strategies Evaluation (DOSE), the vexing issue of optimal administration of furosemide in patients with acute decompensated heart failure was tackled. In addition to the trial providing results that are clinically relevant, it also provides a model for future drug trials by addressing parameters such as dose, method of delivery, and duration of therapy.
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Acknowledgements
This work was supported by grants from the National Institute of Health (RO1 HL36634 and PO1 HL76611) and the Mayo Foundation.
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J. C. Burnett is Chair of the Scientific Advisory Board for Nile Therapeutics. L. C. Costello-Boerrigter declares no competing interests.
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Costello-Boerrigter, L., Burnett, J. Furosemide—to DOSE or not to DOSE, that is the question. Nat Rev Cardiol 8, 365–366 (2011). https://doi.org/10.1038/nrcardio.2011.74
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DOI: https://doi.org/10.1038/nrcardio.2011.74
