Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Coronary artery disease

How should the STICH trial results affect clinical practice?

The STICH trial showed that CABG surgery does not necessarily improve cardiovascular outcomes in patients with coronary artery disease and left ventricular dysfunction who are receiving optimal medical therapy. However, surgical revascularization should still be considered if the coronary artery disease is severe and viable myocardium can be identified.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Velazquez, E. J. et al. Coronary-artery bypass surgery in patients with left ventricular dysfunction. N. Engl. J. Med. 364, 1607–1616 (2011).

    Article  CAS  Google Scholar 

  2. Bonow, R. O. et al. Myocardial viability and survival in ischemic left ventricular dysfunction. N. Engl. J. Med. 364, 1617–1625 (2011).

    Article  CAS  Google Scholar 

  3. Fang, J. C. Underestimating medical therapy for coronary disease ... again. N. Engl. J. Med. 364, 1671–1673 (2011).

    Article  CAS  Google Scholar 

  4. Boden, W. E. et al. Optimal medical therapy with or without PCI for stable coronary disease. N. Engl. J. Med. 356, 1503–1516 (2007).

    Article  CAS  Google Scholar 

  5. Velazquez, E. J. et al. The rationale and design of the Surgical Treatment for Ischemic Heart Failure (STICH) trial. J. Thorac. Cardiovasc. Surg. 134, 1540–1547 (2007).

    Article  Google Scholar 

  6. Jones, R. H. et al. Coronary bypass surgery with or without surgical ventricular reconstruction. N. Engl. J. Med. 360, 1705–1717 (2009).

    Article  CAS  Google Scholar 

  7. Jones, R. H. et al. STICH (Surgical Treatment for Ischemic Heart Failure) trial enrollment. J. Am. Coll. Cardiol. 56, 490–498 (2010).

    Article  Google Scholar 

  8. Eagle, K. A. et al. ACC/AHA 2004 guideline update for coronary artery bypass graft surgery: Summary article: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to update the 1999 guidelines for coronary artery bypass graft surgery). J. Am. Coll. Cardiol. 44, 1146–1154 (2004).

    Article  Google Scholar 

Download references

Acknowledgements

M. J. Mack was a local principal investigator for the Medical City Dallas site in the STICH trial, but was not involved in the analysis of data or in writing the trial report.

Author information

Authors and Affiliations

Authors

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mack, M. How should the STICH trial results affect clinical practice?. Nat Rev Cardiol 8, 427–428 (2011). https://doi.org/10.1038/nrcardio.2011.103

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrcardio.2011.103

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing