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Congenital heart conditions

The 'headache' of assessing a link between PFO and migraine

Nature Reviews Cardiology volume 7, pages 361–362 (2010)Cite this article

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The relationship between patent foramen ovale and migraine is a hotly debated issue. Conflicting data on the association or independence of these conditions have been reported by various study groups around the world. Now, a large-scale case–control study has shown no association between the two entities; however, there were a number of methodological flaws in this study and we are unlikely to see the end of the controversy in the near future.

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Figure 1: A personal view on how future studies of migraine and PFO should be conducted.

References

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Authors and Affiliations

  1. Section of Adult Congenital and Adult Heart Disease, Cardiovascular Diagnosis and Endoluminal Interventions, Rovigo General Hospital, Via W. A. Mozart 9, Legnago, 37040, Verona, Italy

    Gianluca Rigatelli

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  1. Gianluca Rigatelli
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Rigatelli, G. The 'headache' of assessing a link between PFO and migraine. Nat Rev Cardiol 7, 361–362 (2010). https://doi.org/10.1038/nrcardio.2010.73

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