Whether thiazolidinediones should be used to treat patients with type 2 diabetes mellitus is controversial, as studies on the cardiovascular effects of these drugs have produced conflicting results. A trial in which rosiglitazone and glipizide were compared supports earlier findings that rosiglitazone does not have an adverse effect on the progression of coronary atherosclerosis.
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Farkouh, M., Fuster, V. Making sense of the rosiglitazone controversy. Nat Rev Cardiol 7, 366–367 (2010). https://doi.org/10.1038/nrcardio.2010.69
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DOI: https://doi.org/10.1038/nrcardio.2010.69