Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Coronary artery disease

Platelet activity: an obstacle for successful PCI

Nature Reviews Cardiology volume 6, pages 391–392 (2009)Cite this article

Dual antiplatelet therapy with aspirin and clopidogrel is effective in limiting adverse coronary thromboischemic events in most patients undergoing coronary stenting. However, platelet reactivity to clopidogrel is variable and stent thrombosis can occur suddenly and unexpectedly in up to 3% of patients. Is responsiveness to clopidogrel an indicator of risk of post-treatment thromboischemic events?

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Estimation of residual platelet activity after coronary stenting.

References

  1. Spaulding, C. et al. Sirolimus-eluting versus uncoated stents in acute myocardial infarction. N. Engl. J. Med. 355, 1093–1104 (2006).

    Article  CAS  Google Scholar 

  2. Neumann, F. J. et al. Prospective evaluation of hemostatic predictors of subacute stent thrombosis after coronary Palmaz-Schatz stenting. J. Am. Coll. Cardiol. 27, 15–21 (1996).

    Article  CAS  Google Scholar 

  3. Müller, I. et al. Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement. Thromb. Haemost. 89, 783–787 (2003).

    Article  Google Scholar 

  4. Geisler, T. et al. Low response to clopidogrel is associated with cardiovascular outcome after coronary stent implantation. Eur. Heart J. 27, 2420–2425 (2006).

    Article  CAS  Google Scholar 

  5. Snoep, J. D. et al. Clopidogrel nonresponsiveness in patients undergoing percutaneous coronary intervention with stenting: a systematic review and meta-analysis. Am. Heart J. 154, 221–231 (2007).

    Article  CAS  Google Scholar 

  6. Sibbing, D. et al. Platelet reactivity after clopidogrel treatment assessed with point-of-care analysis and early drug-eluting stent thrombosis. J. Am. Coll. Cardiol. 53, 849–856 (2009).

    Article  CAS  Google Scholar 

  7. Gurbel, P. A. et al. Clopidogrel effect on platelet reactivity in patients with stent thrombosis. J. Am. Coll. Cardiol. 46, 1827–1832 (2005).

    Article  CAS  Google Scholar 

  8. Buonamici, P. et al. Impact of platelet reactivity after clopidogrel administration on drug-eluting stent thrombosis. J. Am. Coll. Cardiol. 49, 2312–2317 (2007).

    Article  CAS  Google Scholar 

  9. Hulot, J.-S. & Fuster, V. Personalized medicine for clopidogrel resistance? Nat. Rev. Cardiol. 6, 334–336 (2009).

    Article  CAS  Google Scholar 

  10. Geisler, T. et al. The residual platelet aggregation after deployment of intracoronary stent (PREDICT) score. J. Thromb. Haemost. 6, 54–61 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cardiology, University of Tübingen, Germany

    Meinrad Gawaz & Tobias Geisler

Authors
  1. Meinrad Gawaz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tobias Geisler
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tobias Geisler.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gawaz, M., Geisler, T. Platelet activity: an obstacle for successful PCI. Nat Rev Cardiol 6, 391–392 (2009). https://doi.org/10.1038/nrcardio.2009.76

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrcardio.2009.76

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing