Despite angiographically successful primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction, microcirculatory failure is common and leads to an increased risk of morbidity and mortality. The administration of intracoronary streptokinase immediately after PCI may improve outcomes and provides a promising potential therapy for the future.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Rentrop, P. et al. Selective intracoronary thrombolysis in acute myocardial infarction and unstable angina pectoris. Circulation 63, 307–317 (1981).
DeWood, M. A. et al. Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction. N. Engl. J. Med. 303, 897–902 (1980).
GISSI Investigators Group. Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Lancet 327, 397–401 (1986).
Sezer, M. et al. Effect of intracoronary streptokinase administered immediately after primary percutaneous coronary intervention on long-term left ventricular infarct size, volumes, and function. J. Am. Coll. Cardiol. 54, 1065–1071 (2009).
Antman, E. M. et al. 2007 focused updated of the ACC/AHA 2004 guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines: Developed in collaboration with the Canadian Cardiovascular Society endorsed by the American Academy of Family Physicians: 2007 Writing group to review new evidence and update the ACC/AHA 2004 guidelines for the management of patients with ST-elevation myocardial infarction, writing on behalf of the 2004 writing committee. Circulation 117, 296–329 (2008).
Van de Werf, F. et al. Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: the Task Force on the Management of ST-segment Elevation Acute Myocardial Infarction of the European Society of Cardiology. Eur. Heart J. 29, 2909–2945 (2008).
Buller, C. E. et al. ST-segment recovery and outcome after primary percutaneous coronary intervention for ST-elevation myocardial infarction: insights from the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial. Circulation 118, 1335–1346 (2008).
Fischell, T. A. Pharmaceutical interventions for the management of no-reflow. J. Invasive Cardiol. 20, 374–379 (2008).
Armstrong, P. W. & Collen, D. Fibrinolysis for acute myocardial infarction: Current status and new horizons for pharmacological reperfusion, part 1. Circulation 103, 2862–2866 (2001).
Sezer, M. et al. Intracoronary streptokinase after primary percutaneous coronary intervention. N. Engl. J. Med. 356, 1823–1834 (2007).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Armstrong, P. Intracoronary streptokinase in acute myocardial infarction. Nat Rev Cardiol 7, 67–69 (2010). https://doi.org/10.1038/nrcardio.2009.230
Issue Date:
DOI: https://doi.org/10.1038/nrcardio.2009.230