Nature Reviews Cancer 14, 786–800 (2014)

In the version of this article that was originally published, there were errors in parts of the text referring to the temozolomide-associated mutation signature. In Table 2, the resulting base should be a T and the resulting base change should be C→T. In Box 1, example 3 should compare the overlapping mutation signatures of tobacco and DNA polymerase ε, not those of tobacco and temozolomide. These errors have now been corrected online.