Hu et al. analysed 130 samples of cervical intraepithelial neoplasia and cervical carcinoma, and identified human papillomavirus (HPV) integration sites. They confirmed previously reported integration sites and also identified new ones. In addition, they uncovered changes in gene expression resulting from viral integration, including increased levels of MYC. Importantly, they found that there were sequence microhomologies between the HPV genome and the integration sites, strongly indicating that viral integration occurs via microhomology-mediated DNA repair.
References
Hu, Z. et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nature Genet. http://dx.doi.org/10.1038/ng.3178 (2015)
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Alderton, G. Similar but different. Nat Rev Cancer 15, 69 (2015). https://doi.org/10.1038/nrc3905
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DOI: https://doi.org/10.1038/nrc3905