Using desorption electrospray ionization (DESI) mass spectrometry to detect the oncometabolite 2-hydroxyglutarate (2-HG) in surgically resected gliomas, Santagata, Eberlin and colleagues showed that those gliomas with mutant isocitrate dehydrogenase (IDH) could be rapidly identified during surgery. Detection of 2-HG revealed the tumour margins and could thus be used to improve surgery and patient care.
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01 August 2014
The article incorrectly stated the DOI number for the original research paper; it should have been 10.1073/pnas.1404724111. The error has been corrected in the online version of the article.
References
Santagata, S. et al. Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery. Proc. Natl Acad. Sci. USA http://dx.doi.org/10.1073/pnas.1404724111 (2014)
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Alderton, G. Molecular detection to improve surgery. Nat Rev Cancer 14, 515 (2014). https://doi.org/10.1038/nrc3796
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DOI: https://doi.org/10.1038/nrc3796
