A comparison of genomic data from 47 ovarian cancer cell lines with serous ovarian cancer data from The Cancer Genome Atlas showed substantial differences between commonly used ovarian cancer cell lines and this cancer type. Several rarely used cell lines more closely resemble the human disease and therefore seem to be more suitable cell line models.
References
Domcke, S. et al. Evaluating cell lines as tumour models by comparison of genomic profiles. Nature Comm. http://dx.doi.org/10.1038/ncomms3126 (2013)
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McCarthy, N. Getting it right. Nat Rev Cancer 13, 520 (2013). https://doi.org/10.1038/nrc3577
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DOI: https://doi.org/10.1038/nrc3577
