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Ovarian cancer

At the starting line

Nature Reviews Cancer volume 13, pages 296–297 (2013)Cite this article

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hilum cells are susceptible to transformation

Aldehyde dehydrogenase 1 (ALDH1) is a marker of stem and progenitor cells in several tissues, so the authors separated primary OSE cells into those expressing or those not expressing members of the ALDH family using fluorescence-activated cell sorting. ALDH+ cells represented a small proportion of the total cells (5.3%), and single ALDH+ cells formed spheres at a higher frequency in vitro than ALDH− cells. Furthermore, in ovarian tissues from several strains of mice, cells specifically positive for ALDH1 were primarily found in the hilum, and cells microdissected from the hilum formed spheres that could be propagated for at least seven generations. Bromodeoxyuridine (BrdU) pulse-chase experiments indicated that the ALDH1+ cells in the hilum proliferate slowly relative to other ovarian tissues and, interestingly, the number of BrdU+ cells in the hilum increased just after ovulation, indicating that these cells are activated to repair the OSE following ovulation.

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ORIGINAL RESEARCH PAPER

  1. Flesken-Nikitin, A. et al. Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche. Nature 495, 241–245 (2013)

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  1. Sarah Seton-Rogers
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Seton-Rogers, S. At the starting line. Nat Rev Cancer 13, 296–297 (2013). https://doi.org/10.1038/nrc3510

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