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Unifying metastasis — integrating intravasation, circulation and end-organ colonization

Nature Reviews Cancer volume 12, pages 445446 (2012) | Download Citation


Recent technological advances that have enabled the measurement of circulating tumour cells (CTCs) in patients have spurred interest in the circulatory phase of metastasis. Techniques that do not solely rely on a blood sample allow substantial biological interrogation beyond simply counting CTCs.

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The authors would like to thank K. Kadyshevskaya for her help with the figure. This work was supported by PS-06 grant numbers US4CA143970 and US4CA143906 from the National Cancer Institute (NCI), USA. The content is solely the responsibility of the authors and does not necessarily represent the views of the NCI.

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  1. Integrated Mathematical Oncology, Moffitt Cancer Center, Tampa, Florida 33612, USA.

    • Jacob Scott
    •  & Alexander R. A. Anderson
  2. Oxford University Centre for Mathematical Biology, Mathematical Institute, Oxford OX1 3LB, UK.

    • Jacob Scott
  3. Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

    • Peter Kuhn


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Competing interests

The authors declare no competing financial interests.

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Correspondence to Jacob Scott or Alexander R. A. Anderson.

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