Happy Birthday! We are 10-years-old this month and in the mood to celebrate, but how? Cakes might be a good idea, as might reminiscing, but looking towards the future and the possibilities that could be just around the corner seems to be the right way to go. The personal devastation that is wrought by a diagnosis of cancer has not diminished and there is still much to do.

So, what might the next decade have in store for us? Opinions are likely to be divided on how best to pursue more effective cancer treatments and are also likely to vary from country to country. To reflect this, we asked four top scientists from around the world for their thoughts. You can find their considered opinions on page 749 in our first ever Viewpoint article.

We are also launching a new series of articles that focus on the next 10 years of cancer research. The first of these, on the rapidly expanding field of epigenetics and cancer, is on page 726. Stephen B. Baylin and Peter A. Jones suggest viable areas for research and development in the coming years. In a similar vein, Nilay Sethi and Yibin Kang, on page 735, take a look at metastasis and how genomic and other systems level approaches can be used to find better treatments.

Finally, a birthday celebration always includes a thank you and ours is no exception. We would like to thank all of the scientists and clinicians who have written and/or refereed for Nature Reviews Cancer and all of the editors who have helped to make the journal such a success. Thank you also for reading (and citing) our contents. Ladies and gentleman, please raise your glasses: the toast is to the future and to better treatments for cancer patients. Cheers!