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MicroRNA

Stage-specific signatures

Nature Reviews Cancer volume 9, pages 766–767 (2009)Cite this article

Normal, hyperplastic and angiogenic islets, primary tumours and liver metastases from RIP1-Tag2 mice were profiled for expression of all known mouse miRNAs, and this revealed that each stage had specific differences in miRNA expression. Interestingly, several of the miRNAs upregulated in hyperplastic and angiogenic islets are known to be expressed in haematopoietic cells, and the authors confirmed that the increased expression of these miRNAs corresponded to an increase in immune cell infiltration rather than a change to the expression in tumour cells.

By comparing primary tumours and liver metastases, the authors discovered that a small subset of primary tumours had an miRNA signature that was similar to metastases rather than to other primary tumours. It is possible that these 'metastasis-like' primary PNETs represent tumours that are more likely to metastasize, and therefore the propensity to metastasize may be determined early in tumorigenesis. Decreased expression of the miR-200 family of miRNAs, leading to the loss of E-cadherin expression through the increased expression of the transcriptional repressor ZEB1, was substantial in both metastasis-like primary tumours and metastases.

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References

ORIGINAL RESEARCH PAPER

  1. Olson, P. et al. MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer. Genes Dev. 23, 2152–2165 (2009)

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FURTHER READING

  1. Gibbons, D. L. et al. Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression. Genes Dev. 23, 2140–2151 (2009)

    Article  CAS  Google Scholar 

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Authors
  1. Sarah Seton-Rogers
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Seton-Rogers, S. Stage-specific signatures. Nat Rev Cancer 9, 766–767 (2009). https://doi.org/10.1038/nrc2752

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