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Genetics

Networks uncover new cancer susceptibility suspect

Nature Reviews Cancer volume 7, pages 816–817 (2007)Cite this article

The authors sought to construct a network around four genes that are known to be associated with breast cancer: BRCA1, BRCA2 , ataxia telangiectasia mutated ( ATM ) and checkpoint homologue ( CHEK2 ). They used published expression data from normal cells to identify 164 other genes, the expression of which correlated with all four of their reference genes. The relevance of these genes for the BRCA-related network was confirmed by the fact that their expression was in many cases upregulated in tumours from carriers of BRCA1 mutations compared with sporadic tumours.

This list was integrated with published functional genomic data about interactions between the genes on the list. The resultant network consisted of 118 genes and proteins, with 321 direct and 545 indirect interactions. One of the most highly connected nodes in the network, and the one with the closest coexpression with BRCA1, was HMMR, which probably has a role in centrosome function.

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References

ORIGINAL RESEARCH PAPER

  1. Pujana, M. A. et al. Network modeling links breast cancer susceptibility and centrosome dysfunction. Nature Genet. 7 October 2007 (doi:10.1038/ng.2007.2)

FURTHER READING

  1. Jensen, L. J., Saric, J. & Bork, P. Literature mining for the biologist: from information retrieval to biological discovery. Nature Rev. Genet. 7, 119–129 (2006)

    Article  CAS  Google Scholar 

  2. Badano, J. L., Teslovich, T. M. & Katsanis, N. The centrosome in human genetic disease. Nature Rev. Genet. 6, 194–205 (2005)

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Authors
  1. Patrick Goymer
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Goymer, P. Networks uncover new cancer susceptibility suspect. Nat Rev Cancer 7, 816–817 (2007). https://doi.org/10.1038/nrc2263

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  • DOI: https://doi.org/10.1038/nrc2263

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