Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Tumour budding in colorectal cancer: molecular rationale for clinical translation

Precision medicine and personalized health care call for reproducible and standardized predictive and prognostic biomarkers that can influence the clinical management of patients with cancer. In colorectal cancer, tumour budding — a histological manifestation of tumour cell invasion that is likened to epithelial–mesenchymal transition — is now emerging as one such factor.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Lugli, A. et al. Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016. Mod. Pathol. 30, 1299–1311 (2017).

    Article  Google Scholar 

  2. 2

    Rogers, A. C. et al. Systematic review and meta-analysis of the impact of tumour budding in colorectal cancer. Br. J. Cancer 115, 831–840 (2016).

    CAS  Article  Google Scholar 

  3. 3

    Grigore, A. D., Jolly, M. K., Jia, D., Farach-Carson, M. C. & Levine, H. Tumor budding: the name is EMT. Partial EMT. J. Clin. Med. https://doi.org/10.3390/jcm5050051 (2016).

  4. 4

    De Smedt, L. et al. Expression profiling of budding cells in colorectal cancer reveals an EMT-like phenotype and molecular subtype switching. Br. J. Cancer 116, 58–65 (2017).

    CAS  Article  Google Scholar 

  5. 5

    Knudsen, K. N., Lindebjerg, J., Nielsen, B. S., Hansen, T. F. & Sorensen, F. B. MicroRNA-200b is downregulated in colon cancer budding cells. PLOS One 12, e0178564 (2017).

    Article  Google Scholar 

  6. 6

    Galvan, J. A. et al. TWIST1 and TWIST2 promoter methylation and protein expression in tumor stroma influence the epithelial-mesenchymal transition-like tumor budding phenotype in colorectal cancer. Oncotarget 6, 874–885 (2015).

    Article  Google Scholar 

  7. 7

    Bronsert, P. et al. Cancer cell invasion and EMT marker expression: a three-dimensional study of the human cancer-host interface. J. Pathol. 234, 410–422 (2014).

    CAS  Article  Google Scholar 

  8. 8

    Centeno, I. et al. DNA profiling of tumor buds in colorectal cancer indicates that they have the same mutation profile as the tumor from which they derive. Virchows Arch. 470, 341–346 (2017).

    Article  Google Scholar 

  9. 9

    Lugli, A. et al. CD8+ lymphocytes/ tumour-budding index: an independent prognostic factor representing a 'pro-/anti-tumour' approach to tumour host interaction in colorectal cancer. Br. J. Cancer 101, 1382–1392 (2009).

    CAS  Article  Google Scholar 

  10. 10

    Brabletz, T., Jung, A., Spaderna, S., Hlubek, F. & Kirchner, T. Opinion: migrating cancer stem cells — an integrated concept of malignant tumour progression. Nat. Rev. Cancer 5, 744–749 (2005).

    CAS  Article  Google Scholar 

Download references

Acknowledgements

The authors would like to acknowledge J. R. Jass, our friend and mentor who inspired much of the original works on tumour budding in CRC, as well as our colleagues from the International Tumour Budding Consensus Conference.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Inti Zlobec.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Zlobec, I., Lugli, A. Tumour budding in colorectal cancer: molecular rationale for clinical translation. Nat Rev Cancer 18, 203–204 (2018). https://doi.org/10.1038/nrc.2018.1

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing