Lechman, Gentner et al. identified a prognostic microRNA (miRNA) signature from leukaemia stem cells (LSCs) in human acute myeloid leukaemia (AML) samples. One miRNA in this signature, miR-126, promoted LSC stem cell characteristics (such as self-renewal) and chemotherapy resistance of LSCs in part through targeting PI3K–AKT–mTOR signalling. However, in normal haematopoietic stem cells (HSCs), miR-126 blocked self-renewal, suggesting that miR-126 inhibition could target LSCs while preserving HSCs.
References
Lechman, E. R., Gentner, B. et al. miR-126 regulates distinct self-renewal outcomes in normal and malignant hematopoietic stem cells. Cancer Cell 29, 214–228 (2016)
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Seton-Rogers, S. Not all stem cells are equal. Nat Rev Cancer 16, 129 (2016). https://doi.org/10.1038/nrc.2016.21
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DOI: https://doi.org/10.1038/nrc.2016.21
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