Abstract
A new approach to the modular, complex systems analysis of nonlinear dynamics of arrested neural cell Differentiation--induced cell proliferation during organismic development and the analogous cell cycling network transformations involved in carcinogenesis is proposed. Neural tissue arrested differentiation that induces cell proliferation during perturbed development and Carcinogenesis are complex processes that involve dynamically inter-connected biomolecules in the intercellular, membrane, cytosolic, nuclear and nucleolar compartments. Such 'dynamically inter-connected' biomolecules form numerous inter-related pathways referred to as 'molecular networks'. One such family of signaling pathways contains the cell cyclins. Cyclins are proteins that link several critical pro-apoptotic and other cell cycling/division components, including the tumor suppressor gene TP53 and its product, the Thomsen-Friedenreich antigen (T antigen), Rb, mdm2, c-Myc, p21, p27, Bax, Bad and Bcl-2, which play major roles in various neoplastic transformations of many tissues.The novel theoretical analysis presented here is based on recently published studies of arrested cell differentiation that normally leads to neural system formation during early developmental stages; the perturbed development may involve cyclin signaling and cell cycling responsible for rapidly induced cell proliferation without differentiation into neural cells in such experimental studies.
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Prisecaru, V., Baianu, I. Complex Systems Analysis of Arrested Neural Cell Differentiation during Development and Analogous Cell Cycling Models in Carcinogenesis. Nat Prec (2012). https://doi.org/10.1038/npre.2012.7101.2
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DOI: https://doi.org/10.1038/npre.2012.7101.2
Keywords
- Cell cycling
- control of cell division
- neoplastic transformation in carcinogenesis
- p27 Inhibition
- p53 inactivation
- essential roles of high c-Myc
- proteomics coupled genomes via signaling pathways
- mechanisms of neoplastic transformations of cells
- topological grupoid models of genetic networks in cancer cells
- hTERT activation of telomerase biosynthesis in malignant Cell Transformation
- Rational Clinical trials
- individualized medicine and potential for optimized Radio-Chemo- Gene- and Immuno- therapies of cancers
- Łukasiewicz models of genetic networks
- genome and cell interactomics models in terms of categories of Łukasiewicz logic algebras and Lukasiewicz Topos
- n-valued Łukasiewicz algebraic logic subobject classifier
- genetic network transformations in Carcinogenesis
- developmental processes and evolutionary biology
- relational biology of archea
- yeast and higher eukaryotic organisms
- nonlinear dynamics in non-random hierarchic genetic networks
- natural transformations of organismic structures in molecular biology