Abstract
To truly understand living systems they must be viewed as a whole. In order to achieve this and to come to some law to which living systems obey, data obtained on cells, tissues and organs should be integrated. Because there are no such laws yet, there is usually a long path for physiological findings obtained by reductionist approaches to be translated into medical practice. The concept and accompanying equations of homeostasis presented here are aimed to develop biological laws and to bridge this gap between physiology and medicine. The concept of homeostasis takes into account energy input and output, enlisting all relevant contributors. In homeostasis, changes in the input should equal changes in the output within any specific period of time. What I suggest here is that if the system is out of homeostasis, the homeostasis may be regained by changing any of the input or output components in a proper manner, not only the one that has been changed first. It is important to note that the concept is primary addressing adult human physiology. Proposed equation should enable for the new lab findings regarding any pathophysiological conditions to find a more direct use in medicine. It should also ease ‘decision making’ in medicine and make therapy development and treatment outcome more straightforward and predictable. Finally, to recognize the basic laws of living systems enables for evolutionary adaptations and processes to be understood better.
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Spasojevic, I. Integrative concept of homeostasis: translating physiology into medicine. Nat Prec (2012). https://doi.org/10.1038/npre.2012.6741.2
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DOI: https://doi.org/10.1038/npre.2012.6741.2