Abstract
Reactome is a free, open-source, open access, pathway database. Currently, Reactome has over 5000 human proteins, involved in over 4000 manually curated reactions. Additionally, it has nearly 30,000 reactions inferred by orthology projection from human to 20 other model organisms. Facilities exist for exporting single pathways or the entire database to either BioPax or SBML. SBML generation now uses libSBML, ensuring syntactic correctness, and has adopted MIRIAM URIs for references to external databases. For the future, we anticipate that users will be able to submit a list of species to Reactome and obtain as an output customized BioPax or SBML, based on reactions extracted from Reactome.