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Resveratrol Increases Intracellular NAD+ Levels Through Up regulation of The NAD+ Synthetic Enzyme Nicotinamide Mononucleotide Adenylyltransferase
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Resveratrol Increases Intracellular NAD+ Levels Through Up regulation of The NAD+ Synthetic Enzyme Nicotinamide Mononucleotide Adenylyltransferase

  • Ross Grant1 

Nature Precedings (2010)Cite this article

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Abstract

Resveratrol is a polyphenol with major health benefits that is thought to operate through direct activation of the 'anti-aging' enzyme SIRT1. However recent reports have challenged this 'direct-activation' hypothesis, suggesting the mechanism by which resveratrol increases SIRT1 function is still unknown. We report for the first time that resveratrol induces a dose dependent increase in activity of the NAD+ synthetic enzyme nicotinamide mononucleotide adenylyl transferase (NMNAT1). Activation of NMNAT1 by resveratrol in cultured primary human astrocytes and neurons increased NAD+ levels by up to 5 fold. As SIRT1 requires NAD+ as a substrate to perform its gene silencing function, higher NAD+ levels will enhance SIRT1 activity. This finding suggests that resveratrol may promote SIRT1 function by enhancing NAD+ synthesis in whole cell systems without requiring direct activation.

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  1. University of New South Wales, Pharmacology https://www.nature.com/nature

    Ross Grant

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  1. Ross Grant
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Correspondence to Ross Grant.

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Grant, R. Resveratrol Increases Intracellular NAD+ Levels Through Up regulation of The NAD+ Synthetic Enzyme Nicotinamide Mononucleotide Adenylyltransferase. Nat Prec (2010). https://doi.org/10.1038/npre.2010.4421.1

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  • Received: 05 May 2010

  • Accepted: 05 May 2010

  • Published: 05 May 2010

  • DOI: https://doi.org/10.1038/npre.2010.4421.1

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Keywords

  • resveratrol
  • NAD+
  • SIRT

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