Just-in-time assembly of cell-cycle protein complexes

Abstract

Our comparative analysis of eukaryotic cell-cycle complexes reveals that the identity of the periodically expressed subunits differs significantly between organisms and is often mirrored by changes in cell-cycle-dependent phosphorylation of the protein products. This indicates that many different solutions have evolved for just-in-time assembly of the same molecular machines.

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Correspondence to Lars Jensen.

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Jensen, L., de Lichtenberg, U., Jensen, T. et al. Just-in-time assembly of cell-cycle protein complexes. Nat Prec (2008). https://doi.org/10.1038/npre.2008.2273.1

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Keywords

  • cell cycle
  • complexes
  • degradation
  • Evolution
  • expression
  • phosphorylation
  • regulation

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