Abstract
We report the first known example of spontaneous, naturally occurring fibrodysplasia ossificans progressiva (FOP) in a mammal. The Southeast Asian mouse deer of the genus Tragulus (Artiodactyla: Tragulidae) have an osseous sheath covering the lower back and upper thigh region consistent with the clinical definition of FOP. This heterotophic bone deposition is sex related apparently with a genetic basis - it only occurs in males and is lacking in females; it is present in all adults males, including both wild obtained and zoo bred animals. Tragulus may offer the opportunity to examine many of the disease's most significant attributes experimentally.
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Rothschild, B., Martin, L. & Timm, R. New Spontaneous Model of Fibrodysplasia Ossificans Progressiva. Nat Prec (2008). https://doi.org/10.1038/npre.2008.1541.1
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DOI: https://doi.org/10.1038/npre.2008.1541.1