Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Raman spectroscopy

Watching a molecule breathe

Marrying the single-molecule detection ability of surface-enhanced Raman scattering with the extreme time resolution of ultrafast coherent spectroscopy enables the vibrations of a single molecule to be observed.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Figure 1: TR-SECARS.


  1. Yampolsky, S. et al. Nature Photon. 8, 650–656 10.1038/nphoton.2014.143(2014).

    Article  ADS  Google Scholar 

  2. Moerner, W. E. & Kador, L. Phys. Rev. Lett. 62, 2535–2538 (1989).

    Article  ADS  Google Scholar 

  3. Orrit, M. & Bernard, J. Phys. Rev. Lett. 65, 2716–2719 (1990).

    Article  ADS  Google Scholar 

  4. Betzig, E. & Chichester, R. J. Science 262, 1422–1425 (1993).

    Article  ADS  Google Scholar 

  5. Xie, X. S. & Dunn, R. C. Science 265, 361–364 (1994).

    Article  ADS  Google Scholar 

  6. Ambrose, W. P., Goodwin, P. M., Keller, R. A. & Martin, J. C. Science 265, 364–367 (1994).

    Article  ADS  Google Scholar 

  7. Betzig, E. et al. Science 313, 1642–1645 (2006).

    Article  ADS  Google Scholar 

  8. Brinks, D. et al. Nature 465, 905–908 (2010).

    Article  ADS  Google Scholar 

  9. Nie, S. & Emory, S. R. Science 275, 1102–1106 (1997).

    Article  Google Scholar 

  10. Kneipp, K. et al. Phys. Rev. Lett. 78, 1667–1670 (1997).

    Article  ADS  Google Scholar 

  11. Le Ru, E. C., Meyer, M. & Etchegoin, P. G. J. Phys. Chem. B 110, 1944–1948 (2006).

    Article  Google Scholar 

  12. Min, W., Freudiger, C. W., Lu, S. & Xie, X. S. Ann. Rev. Phys. Chem. 62, 507–530 (2011).

    Article  ADS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Niek F. van Hulst.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Piatkowski, L., Hugall, J. & van Hulst, N. Watching a molecule breathe. Nature Photon 8, 589–591 (2014).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing