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Host response: Neurons loosen the gRIP of death

RIPK3 is a well-known mediator of the necroptosis cell death pathway, which is an important antiviral defence mechanism. In an unexpected twist, RIPK3 has now been shown to also drive neuroprotective inflammation in the central nervous system during West Nile virus infection in a cell-death-independent manner.

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Figure 1: RIPK3 activation drives chemokine expression in neurons, but not other cell types.

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Correspondence to Jason W. Upton.

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Ragan, K., Upton, J. Host response: Neurons loosen the gRIP of death. Nat Microbiol 2, 17090 (2017). https://doi.org/10.1038/nmicrobiol.2017.90

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