RIPK3 is a well-known mediator of the necroptosis cell death pathway, which is an important antiviral defence mechanism. In an unexpected twist, RIPK3 has now been shown to also drive neuroprotective inflammation in the central nervous system during West Nile virus infection in a cell-death-independent manner.
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Sridharan, H. & Upton, J. W. Trends Microbiol. 22, 199–207 (2014).
Guo, H., Kaiser, W. J. & Mocarski, E. S. Med. Microbiol. Immunol. 204, 439–448 (2015).
Daniels, B. P. et al. Cell 169 301–313 (2017).
Suthar, M. S., Diamond, M. S. & Gale, M. Jr. Nat. Rev. Microbiol. 11, 115–128 (2013).
Lim, J. K. & Murphy, P. M. Exp. Cell. Res. 317, 569–574 (2011).
Orozco, S. et al. Cell Death Differ. 21, 1511–1521 (2014).
Moriwaki, K., Balaji, S., Bertin, J., Gough, P. J. & Chan, F. K. Cell Rep. 18, 2441–2451 (2017).
Moriwaki, K. et al. Immunity 41, 567–578 (2014).
Najjar, M. et al. Immunity 45, 46–59 (2016).
Zhao, H. et al. Cell Death Dis. 6 e1975 (2015).
Zhang, S. Y. et al. Science 317, 1522–1527 (2007).
Suh, H. S., Brosnan, C. F. & Lee, S. C. Curr. Top. Microbiol. Immunol. 336, 63–81 (2009).
The authors declare no competing financial interests.
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Ragan, K., Upton, J. Host response: Neurons loosen the gRIP of death. Nat Microbiol 2, 17090 (2017). https://doi.org/10.1038/nmicrobiol.2017.90