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Bacterial physiology: Persisters run out of fuel

Nature Microbiology volume 1, Article number: 16060 (2016) Cite this article

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Multidrug tolerant bacterial persister cells frequently arise in response to the activation of toxin–antitoxin systems. However, this prevailing view may be less general than assumed. ATP depletion may mediate another route to the persister state for the Gram-positive pathogen Staphylococcus aureus.

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Figure 1: Model of S. aureus persister dynamics.

References

  1. Maisonneuve, E. & Gerdes, K. Cell 157, 539–548 (2014).

    Article  CAS  Google Scholar 

  2. Page, R. & Peti, W. Nature Chem. Biol. 12, 208–214 (2016).

    Article  CAS  Google Scholar 

  3. Bigger, J. Lancet 244, 497–500 (1944).

    Article  Google Scholar 

  4. Conlon, B. P. et al. Nature Microbiol. 1, 16051 (2016).

    Article  CAS  Google Scholar 

  5. Maisonneuve, E. et al. Proc. Natl Acad. Sci. USA 108, 13206–13211 (2011).

    Article  CAS  Google Scholar 

  6. Prax, M. et al. PLoS ONE 11, e0150907 (2016).

    Article  Google Scholar 

  7. Allison, K. R. et al. Nature 473, 216–220 (2011).

    Article  CAS  Google Scholar 

  8. Conlon, B. P. et al. Nature 503, 365–370 (2013).

    Article  CAS  Google Scholar 

  9. Chatterjee, I. et al. Proteomics 9, 1152–1176 (2009).

    Article  CAS  Google Scholar 

  10. Balaban, N. Q. et al. Science 305, 1622–1625 (2004).

    Article  CAS  Google Scholar 

Download references

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  1. Ralph Bertram is in the Research Department of the Paracelsus Medical University in Nuremberg, and is also affiliated with the Department of Microbial Genetics at the University of Tübingen, Prof.-Ernst-Nathan-Str. 1, 90419 Nuremberg, Germany, Auf der Morgenstelle 28/E7, 72076 Tübingen, Germany.,

    Ralph Bertram

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  1. Ralph Bertram
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Correspondence to Ralph Bertram.

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Bertram, R. Bacterial physiology: Persisters run out of fuel. Nat Microbiol 1, 16060 (2016). https://doi.org/10.1038/nmicrobiol.2016.60

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  • DOI: https://doi.org/10.1038/nmicrobiol.2016.60

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